醋酸依替巴肽用途
Eptifibatide, also co-promoted by Schering-Plough/Essex, is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarius barbouri). It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.
1、產品物理參數：
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常用名
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醋酸依替巴肽
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英文名
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Eptifibatide Acetate
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CAS號
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148031-34-9
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分子量
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831.962
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密度
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1.6±0.1 g/cm3
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沸點
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無資料
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分子式
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C35H49N11O9S2
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熔點
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92-98 °C
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閃點
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無資料
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2、醋酸依替巴肽物理化學性質
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密度
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1.6±0.1 g/cm3
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熔點
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92-98 °C
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分子式
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C35H49N11O9S2
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分子量
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831.962
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精*確質量
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831.315613
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PSA
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374.49000
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LogP
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-4.84
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折射率
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1.735
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分子結構
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1、摩爾折射率：208.03
2、摩爾體積（cm3/mol）：518.4
3、等張比容（90.2K）：1530.5
4、表面張力（dyne/cm）：75.9
5、介電常數：無可用的
6、極化率（10-24cm3）：82.47
7、單一同位素質量：831.315612 Da
8、標稱質量：831 Da
9、平均質量：831.9619 Da
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計算化學
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1.疏水參數計算參考值（XlogP）:-2.4
2.氫鍵供體數量:10
3.氫鍵受體數量:12
4.可旋轉化學鍵數量:10
5.互變異構體數量:1000
6.拓撲分子極性表面積377
7.重原子數量:57
8.表面電荷:0
9.復雜度:1520
10.同位素原子數量:0
11.確定原子立構中心數量:0
12.不確定原子立構中心數量:5
13.確定化學鍵立構中心數量:0
14.不確定化學鍵立構中心數量:0
15.共價鍵單元數量:1
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3、醋酸依替巴肽英文別名
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n6-(aminoiminomethyl)-n2-(3-mercapto-1-oxopropyl-l-lysylglycyl-l-a-aspartyl-l-tryptophyl-l-prolyl-l-cysteinamide
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7H-Pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-[4-[(aminoiminomethyl)amino]butyl]docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-
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Mpr-Harg-Gly-Asp-Trp-Pro-Cys-NH2,( Disulfide Bridge:1-7)
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EFTIFIBATIDE
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MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2
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MFCD05662245
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[11-(4-Carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
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Mpr-Harg-Gly-Asp-Trp-Pro-Cys-NH2,( Disulfide Bridg on Mpr and Cys)
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Eptifitide
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INTEGRELIN
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Eptifibatide Acetate
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7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-[4-[(diaminomethylene)amino]butyl]docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-
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